Stage 3 mesothelioma is an advanced stage of this aggressive cancer, and treatment options may be more limited compared to earlier stages. The choice of treatment for stage 3 mesothelioma will depend on various factors, including the patient’s overall health, the location and extent of the cancer, and the individual’s preferences. Treatment options may include:
- Surgery: While surgery is less commonly an option for stage 3 mesothelioma compared to earlier stages, some patients may still benefit from aggressive surgical approaches. This may involve removing the tumor, affected lung, parts of the diaphragm, or other affected tissues. Surgical options might include pleurectomy/decortication (P/D) or extrapleural pneumonectomy (EPP).
- Chemotherapy: Chemotherapy is often a mainstay of treatment for stage 3 mesothelioma. It may be administered before surgery (neoadjuvant) to shrink the tumor or after surgery (adjuvant) to kill any remaining cancer cells. Common chemotherapy drugs used include cisplatin and pemetrexed.
- Radiation therapy: Radiation therapy may be used to target and shrink the tumor, alleviate symptoms, or as part of a multimodal treatment plan. It is often used in combination with surgery or chemotherapy.
- Immunotherapy: Some patients with mesothelioma may be eligible for immunotherapy, which can help the immune system identify and attack cancer cells. Immunotherapy drugs like pembrolizumab and nivolumab have been explored in clinical trials for mesothelioma.
- Targeted therapy: Targeted therapy drugs are designed to specifically target cancer cells by blocking certain pathways or molecules involved in cancer growth. These treatments are often used in combination with chemotherapy.
- Palliative care: Palliative care focuses on improving the patient’s quality of life by managing symptoms and providing emotional support. It can be integrated with other treatments or used alone, depending on the patient’s goals.
- Clinical trials: Participating in clinical trials can provide access to experimental treatments that may not be available otherwise. These trials test new therapies, including novel drugs and treatment combinations, for mesothelioma.
It’s essential for individuals with stage 3 mesothelioma to work closely with a team of healthcare professionals, including oncologists and specialists experienced in treating mesothelioma. Treatment decisions should be tailored to the specific circumstances of the patient. Additionally, patients and their families should seek second opinions and consider the potential benefits and risks of each treatment option.
Early detection and prompt treatment can greatly impact the prognosis and quality of life for individuals with mesothelioma, but even in advanced stages, there are treatment options to help manage the disease and improve the patient’s well-being.