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Peritoneal Mesothelioma Cancer | Causes, Symptoms & Treatment

Peritoneal Mesothelioma Cancer | Causes, Symptoms & Treatment

Peritoneal mesothelioma is a rare and aggressive form of cancer that affects the peritoneum, which is the thin membrane that lines the abdominal cavity. It is primarily caused by exposure to asbestos, a mineral that was commonly used in construction and manufacturing industries before its health hazards were well-known. Here is an overview of peritoneal mesothelioma, including its causes, symptoms, and treatment options:


  1. Asbestos Exposure: The primary cause of peritoneal mesothelioma is the inhalation or ingestion of asbestos fibers. Asbestos was widely used in various industries, including construction, shipbuilding, and manufacturing, due to its heat-resistant properties. Workers in these industries, as well as their family members who may have been exposed to asbestos dust on their clothing, are at a higher risk of developing peritoneal mesothelioma.

Symptoms: The symptoms of peritoneal mesothelioma can be non-specific and may mimic other abdominal conditions. Common symptoms include:

  1. Abdominal Pain: Persistent and often severe abdominal pain is a common early symptom.
  2. Abdominal Swelling: Accumulation of fluid in the abdominal cavity (ascites) can lead to noticeable swelling.
  3. Unexplained Weight Loss: Rapid and unexplained weight loss can occur.
  4. Nausea and Vomiting: These symptoms may arise due to the pressure on the stomach and digestive organs.
  5. Bowel Changes: Changes in bowel habits, such as diarrhea or constipation, may occur.
  6. Fatigue: Generalized weakness and fatigue can be present.

Diagnosis: Diagnosing peritoneal mesothelioma usually involves a combination of medical history review, physical examination, and imaging tests like CT scans or MRI. A definitive diagnosis often requires a biopsy, which involves removing a small sample of tissue for examination under a microscope.

Treatment: Treatment options for peritoneal mesothelioma may include:

  1. Surgery: Depending on the stage and extent of the cancer, surgery may involve removing the tumor (cytoreductive surgery) and heated chemotherapy (hyperthermic intraperitoneal chemotherapy or HIPEC) to kill any remaining cancer cells.
  2. Chemotherapy: Systemic chemotherapy drugs may be used before or after surgery to help shrink tumors and target cancer cells throughout the body.
  3. Radiation Therapy: Radiation therapy may be used to target specific areas of the abdomen, often in combination with surgery or chemotherapy.
  4. Immunotherapy: Clinical trials are investigating the use of immunotherapy drugs to treat peritoneal mesothelioma.
  5. Palliative Care: This focuses on symptom management and improving the patient’s quality of life, especially in cases where the cancer is advanced and not curable.

It’s important for individuals who have been exposed to asbestos and are experiencing symptoms to seek medical attention promptly. Early diagnosis and treatment can improve the prognosis for peritoneal mesothelioma. Additionally, anyone who has been exposed to asbestos should undergo regular medical check-ups and discuss their exposure history with their healthcare provider.